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Neuromuscular toxicity and rhabdomyolysis have been reported from chronic treatment with colchicine in therapeutic dosesespecially in combination with other drugs known to cause this effectPatients with impaired renal function and elderly patientseven those with normal renal and hepatic functionare at increased riskOnce colchicine treatment is ceasedthe symptoms generally resolve within 1 week to several months.
After completion of a courseanother course should not be started for at least 3 days72 hours
Advise the patient to read the FDA-approved patient labelingMedication Guide
Some drugs such as HMG-CoA reductase inhibitors and fibrates may increase the risk of myopathy when combined with colchicine capsulesComplaints of muscle pain or weakness could be an indication to check serum creatinine kinase levels for signs of myopathy.
Take this medication by mouth with or without foodexactly as directed by your doctorDosing recommendations vary widely and may be different from the following recommendationsTaking more than the recommended dose may not increase this drug’s effectiveness and may increase your risk for side effectsAsk your doctor or pharmacist for more details.
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