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Based on the mechanism of actionthe use of prostaglandin-mediated NSAIDsincluding CELEBREXmay delay or prevent rupture of ovarian follicleswhich has been associated with reversible infertility in some womenPublished animal studies have shown that administration of prostaglandin synthesis inhibitors has the potential to disrupt prostaglandin mediated follicular rupture required for ovulationSmall studies in women treated with NSAIDs have also shown a reversible delay in ovulationConsider withdrawal of NSAIDsincluding CELEBREXin women who have difficulties conceiving or who are undergoing investigation of infertility.
Celebrex may also cause stomach or intestinal bleedingwhich can be fatalThese conditions can occur without warning while you are using Celebrexespecially in older adults.
NSAIDsincluding CELEBREX can lead to new onset of hypertension or worsening of preexisting hypertensioneither of which may contribute to the increased incidence of CV eventsPatients taking angiotensin converting enzymeACEinhibitorsthiazide diuretics or loop diuretics may have impaired response to these therapies when taking NSAIDssee DRUG INTERACTIONS
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Anemia has occurred in NSAID-treated patientsThis may be due to occult or gross blood lossfluid retentionor an incompletely described effect on erythropoiesisIf a patient treated with CELEBREX has any signs or symptoms of anemiamonitor hemoglobin or hematocrit.
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