Other drugs which pose a risk include cisapride, diuretics compounds which increase urination , sympathomimetics present in many cold remedies , and colchicine treats gout or gouty arthritis .
Information about Colchicine.
The most common side effects of colchicine capsules include abdominal paindiarrheanauseaand vomiting.
Because colchicine is a substrate for both the CYP3A4 metabolizing enzyme and the P-glycoprotein efflux transporterinhibition of either of these pathways may lead to colchicine-related toxicityInhibition of both CYP3A4 and P-gp by dual inhibitors such as clarithromycin has been reported to produce life-threatening or fatal colchicine toxicity due to significant increases in systemic colchicine levelsThereforeconcomitant use of colchicine capsules and inhibitors of CYP3A4 or P-glycoprotein should be avoidedSee DRUG INTERACTIONSIf avoidance is not possiblereduced daily dose should be considered and the patient should be monitored closely for colchicine toxicityUse of colchicine capsules in conjunction with drugs that inhibit both P-gp and CYP3A4 is contraindicated in patients with renal or hepatic impairmentSee CONTRAINDICATIONS
If you are taking this medication to treat symptoms due to familial Mediterranean fevertell your doctor if your condition does not improve or if it worsens.
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