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CUse with caution if benefits outweigh risksAnimal studies show risk and human studies not available or neither animal nor human studies done.
Cytoxanalthough effective alone in susceptible malignanciesis more frequently used concurrently or sequentially with other antineoplastic drugsThe following malignancies are often susceptible to Cytoxan treatment:
To minimize bladder toxicityincrease normal fluid intake during and for 1-2 days after cyclophosphamide therapymost adult patients will require fluid intake of at least how much dilantin is an overdose 2 L/dayhigh-dose regimens should be accompanied by vigorous hydration with or without mesna therapy.
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