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Disposition of HMG-CoA reductase inhibitorsincluding rosuvastatininvolves OATP1B1 and other transporter proteinsHigher plasma concentrations of rosuvastatin have been reported in very small groups of patientsn=3 to 5who have two reduced function alleles of the gene that encodes OATP1B1SLCO1B1 521TCThe frequency of this genotypei.eSLCO1B1 521 C/Cis generally lower than 5in most racial/ethnic groupsThe impact of this polymorphism on efficacy and/or safety of rosuvastatin has not been clearly established.
Rosuvastatin use is contraindicated during breastfeedingsee CONTRAINDICATIONSLimited data indicate that CRESTOR is present in human milkThere is no available information on the effects of the drug on the breastfed infant or the effects of the drug on milk productionBecause of the potential for serious adverse reactions in a breastfed infantadvise patients that breastfeeding is not recommended during treatment with CRESTOR.
Research has found that most side effects of statins are related to the dose patients takeThe higher the dosethe greater the risk of certain side effects.
It is recommended that liver enzyme tests be performed before the initiation of CRESTORand if signs or symptoms of liver alavert price comparison injury occur.
These are not all the possible side effects of CRESTORFor more informationask your doctor or pharmacist.
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