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Hepatic dysfunctionsometimes severe and usually reversibleincluding increased liver enzymesand hepatocellular and/or cholestatic hepatitiswith or without jaundice have been reportedIn some instanceshepatic failure with fatal outcome has been reported and generally has been associated with serious underlying diseasese.gpreexisting liver diseaseand/or concomitant medicationse.ghepatotoxic agents
Postmarketing reportsAcute pancreatitistongue discolorationtooth discolorationpseudomembranous colitisenteritisRef]
Postmarketing lioresal online reportsHepatic failurehepatocellular jaundiceadverse reactions related to hepatic dysfunctionabnormal hepatic functionliver abnormalitiesRef]
Elevated ASTgreater than 5 times the upper limit of normal5 x ULNand ALTgreater than 5 x ULNwere reported in up to 4and up to 3of patientsrespectively.
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