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In harmonising the contraindicationsthe CHMP decided against including two contraindications that were in the SmPCs of some EU countriesliver impairment and pre-operative use in patients whose receptor status is negative or unknownThe CHMP was of the view that it was more appropriate to include relevant warnings in section 4.4.
You may be advised to take calcium and vitamin D supplements to help prevent bone lossWeight bearing exercise and a healthy diet rich in calcium and vitamin D can also help protect your bone healthYour doctor will check your bone health before starting therapyThis is done with a bone density scanDEXA scanWomen with no weakening of bones prior to aromatase inhibitor therapy will have a follow-up scan around one year after starting therapyand then every one to two yearsIf the scan shows that you already have some bone weakeningyour doctor may order a type of medication called a bisphosphonateThese therapies have been shown to protect the bones from bone loss in women taking aromatase inhibitorsIf the bone density remains stablescans can then be done every two years.
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