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Losartan does not have an agonist effect nor does it block other hormone receptors or ion channels important in cardiovascular regulationFurthermore losartan does not inhibit ACEkininase IIthe enzyme that degrades bradykininConsequentlythere is no potentiation of undesirable bradykinin-mediated effects.
Aspirin or other NSAIDsnonsteroidal anti-inflammatory drugssuch as ibuprofenAdvilMotrinnaproxenAlevecelecoxibdiclofenacindomethacinmeloxicamand others.
When pregnancy is detecteddiscontinue COZAAR as soon as possibleDrugs that cheap prandin generic act directly on the renin-angiotensin system can cause injury and death to the developing fetussee WARNINGS AND PRECAUTIONS
Following oral administrationlosartan is well absorbed and undergoes first-pass metabolismforming an active carboxylic acid metabolite and other inactive metabolitesThe systemic bioavailability of losartan tablets is approximately 33Mean peak concentrations of losartan and its active metabolite are reached in 1 hour and in 3-4 hoursrespectively.
Renal function should be regularly monitored during treatment with losartan as it may deteriorateThis applies particularly when losartan is given in the presence of other conditionsfeverdehydrationlikely to impair renal function.
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