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Sarcina si lactatie Anumite studii pe animale au aratat ca glucocorticoizii administrati la mama in doze mari pot determina malformatii fetaleStudii reproductive umane adecvate nu au fost efectuate cu corticoiziDe aceea folosirea corticosteroizilor in sarcinalactatie sau la femei cu potential fertil se recomanda in cazul in care beneficiile terapiei depasesc evident riscul potential pentru mamaembrion sau fatDeoarece evidenta sigurantei in sarcina este inconsistentamedicamentul va fi folosit in sarcina numai in cazuri de absoluta necesitateCorticosteroizii traverseaza placentaNou-nascutii mamelor care au primit doze substantiale de corticoizi in timpul sarcinii trebuie atent monitorizati si evaluati pentru o posibila insuficienta adrenalianaNu se cunosc efectele corticoizilor asupra travaliului si a expulsiei fetaleCorticoizii trec in laptele matern.
Reversible transaminase elevationsASTALThave been observed following corticosteroid therapyThese changes have generally been small and not associated with any clinical syndromeToxic hepatitis has been reported with high doses of cyclically pulsed IV therapyonset has been several weeks or longerResolution has been reported with discontinuationhoweverrecurrence has been reported with rechallengeRef]
4Product InformationDepo-MedrolmethylPREDNISolone acetatePfizer U.SPharmaceuticals GroupNew YorkNY.
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