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Anticholinergic drugs such as oxybutynin and tolterodineDetroland othersreduce OAB symptoms by relaxing bladder smooth muscle and inhibiting involuntary detrusor contractionsDry mouth has been the limiting adverse effectIn clinical studiesthe oxybutynin patch was associated with fewer systemic adverse effectsincluding dry mouththan the oral drugbut with a high incidence of pruritus at the application site.2.
Urinary or gastric retentionuncontrolled narrow-angle glaucomaor patients at risk for these.
In additionOxytroloxybutyninis only moderately effective for relieving overactive bladder symptomslike all drugs in its classand it can cause dry mouth and constipationThe patch formwhich will be available OTC probably starting next fallcan cause skin reactions at the site of application in about a quarter of patientsin 11 percent of people the reactions are so severethey stop using the patch.
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