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The following adverse reactions have been reported in postmarketing experience for VYTORIN or ezetimibe or simvastatinpruritusalopeciaerythema multiformea variety of skin changese.gnodulesdiscolorationdryness of skin/mucous membraneschanges to hair/nailsdizzinessmuscle crampsmyalgiaarthralgiapancreatitisparesthesiaperipheral neuropathyvomitingnauseaanemiaerectile dysfunctioninterstitial lung diseasemyopathy/rhabdomyolysissee WARNINGS AND PRECAUTIONShepatitis/jaundicefatal and non-fatal hepatic failuredepressioncholelithiasischolecystitisthrombocytopeniaelevations in liver transaminaseselevated creatine phosphokinase.
Take this medication by mouth with or without food as directed by your doctorusually once daily in the evening.
All patients starting therapy with VYTORIN or whose dose of VYTORIN is being increased should be advised of the risk of myopathyincluding rhabdomyolysisand told to report promptly any unexplained muscle paintenderness or weakness particularly if accompanied by malaise or fever or if muscle signs and symptoms persist after discontinuing VYTORINVYTORIN therapy should be discontinued immediately if myopathyis diagnosed or suspectedIn most casesmuscle symptoms and CK increases resolved when simvastatin treatment was promptly discontinuedPeriodic CK determinations may be considered in patients starting therapy with VYTORIN or whose dose is being increasedbut there is no assurance that such monitoring will prevent myopathy.
Contraindicated with VYTORINsee CONTRAINDICATIONS and WARNINGS AND PRECAUTIONS
In one studyconcomitant administration of digoxin with simvastatin resulted in a slight elevation in plasma digoxin concentrationsPatients taking digoxin Costo de orlistat 120 mg should be monitored appropriately when VYTORIN is initiated.
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