Naltrexone is used in various addictive disorders and is also being used as an adjunct for a number of autoimmunity related problems.
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There is also the possibility that a patient who is treated with REVIA could overcome the opioid blockade effect of REVIAAlthough REVIA is a potent antagonistthe blockade produced by REVIA is surmountableThe plasma concentration of exogenous opioids attained immediately following their acute administration may be sufficient to overcome the competitive receptor blockadeThis poses a potential risk to individuals who attempton their ownto overcome the blockade by administering large amounts of exogenous opioidsAny attempt by a patient to overcome the antagonism by taking opioids is especially dangerous and may lead to life-threatening opioid intoxication or fatal overdosePatients should be told of the serious consequences of trying to overcome the opioid blockadesee PATIENT INFORMATION
The safety and efficacy of concomitant use of REVIA and disulfiram is unknownand the concomitant use of two potentially hepatotoxic medications is not ordinarily recommended unless the probable benefits outweigh the known risks.
After opioid detoxificationpatients are likely to have reduced tolerance to opioidsAs the blockade of exogenous opioids provided by REVIA wanes and eventually dissipates completelypatients who have been treated with REVIA may respond to lower doses of opioids than previously usedjust as they would shortly after completing detoxification.
Alcohol-and opioid-dependent patientsincluding those taking REVIAshould be monitored for the development of depression or suicidal thinkingFamilies and caregivers of patients being treated with REVIA should be alerted to the need to monitor patients for the emergence of symptoms of depression or suicidalityand to report such symptoms to the patient’s healthcare provider.
Naltrexone is used along with counseling and social support to help people who have stopped drinking alcohol and using street drugs continue to avoid drinking or using drugsNaltrexone should not be used to treat people who are still using street drugs or drinking large amounts of alcoholNaltrexone is in a class of medications called opiate antagonistsIt works by decreasing the craving for alcohol and blocking the effects of opiate medications and opioid street drugs.
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