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Clinical surveillance of all women using estrogen-alone or estrogen plus progestin therapy is importantAdequate diagnostic measuresincluding directed or random endometrial sampling when indicatedshould be undertaken to rule out malignancy in postmenopausal women with undiagnosed persistent or recurring abnormal genital bleeding.
Some patients dependent on thyroid hormone replacement therapy may require increased doses in order to maintain their free thyroid hormone levels in an acceptable rangeThereforepatients should have their thyroid function monitored more frequently when commencing concurrent treatment in order to maintain their free thyroid hormone levels in an acceptable range.
Therapy should be discontinued if a contra-indication is discovered and in the following situations:
Accelerated prothrombin timepartial thromboplastin timeand platelet aggregation timeincreased platelet countincreased factors IIVII antigenVIII antigenVIII coagulant activityIXXXIIVII-X complexII-VII-X complexand beta-thromboglobulindecreased levels of antifactor Xa and antithrombin IIIdecreased antithrombin III activityincreased levels of fibrinogen and fibrinogen activityincreased plasminogen antigen and activity.
Some patients dependent on thyroid hormone replacement therapy may require increased doses in order to maintain their free thyroid hormone levels in an acceptable rangeThereforepatients should have their thyroid function monitored more frequently when commencing concurrent treatment in order to maintain their free thyroid hormone levels in an acceptable range.
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